Hydrophilic, alkyne-reactive, long-lifetime reagent for click chemistry containing one azide function. Azides react with C≡C triple bonds in either a Cu(I)-catalyzed or Cu-free 1,3-dipolar cycloaddition reaction to triazoles. The dye contains a single positive charge and chloride as the counter-ion.
Applications
Click Chemistry reagent.
Fluorescence lifetime assays.
Fluorescence polarization-based assays of high molecular weight antigens.
Advantages
Highly fluorescent label for proteins and oligos.
High quantum yield (Q.Y.) ~ 80 % (water).
Long fluorescence lifetime of 9 ns in water.
Perfectly suited for excitation with the 380-nm and 404-nm diode lasers.
Large Stokes' shift : > 100 nm.
High fundamental polarization P0 = 475 mP.
Highly soluble in aqueous buffer (500 mg/L at 20 °C)